Results of Radiotherapy and Concomitant Cisplatin Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Uterine Cervix

Abstract

From June 1994 to May 1998, 38 patients with histopathologically proven locally advanced stage 118 IVA squamous cell carcinoma of uterine cervix were treated with radiotherapy and concomitant cisplatin chemotherapy. Radiotherapy was delivered with the combination of high energy external beams and intracavitary high dose rate radiation applications. Eighty one to eighty five Gy was delivered to point A. Cisplatin was given at a dose of 50 mg/rn2 on Day 1 and Day 22 during external beam radiotherapy and subsequently on first intracavitary insertion at day 40 and on last intracavitary insertion around Day 55. Late toxicities were seen in 15.78 % and included rectovaginal fistula, vesicovaginal fistula and rectal ulcers. Overall response was seen in thirty four (89.47%) patients. Complete responses were seen in 65.79% patients and partial response in 23.68% patients. Overall survival of 60 % was achieved. It is concluded that radiotherapy and concomitant cisplatin chemotherapy in these patients of locally advanced squamous cell carcinoma of uterine cervix has provided good survival probability and is associated with manageable acute and late toxicities.