Chronic Lead Acetate Nephrotoxicity: A Histological Study on Albino Rats
DOI:
https://doi.org/10.21649/akemu.v17i3.542Abstract
Abstract
Introduction: The human beings are constantly expo-sed to heavy metals in our environment, all of these are capable of combining with wide variety of organic molecules. They are potent enzyme inhibitors, which inactivate the enzyme system of cell. The lead hazards in the environment are identified as a serious Public Health problem particularly in children less than 7 years of age.
Aims: In the present study our aim was to observe histological changes induced in kidney to high light the extent of damage done by chronic lead acetate toxicity.Material and Methods: The Albino rats were expo-sed to lead acetate in a dose of 8 mg/kg body weight and sacrificed after, 7, 14 and 21 days. Their kidneys were studied.
Results: Time scaled treatment with lead acetate re-sults in renal damage. The Proximal convoluted tubu-les showed a damage ranging from cloudy swelling to complete cell death.
Key words: Lead acetate, Toxicity, kidney.
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