In-hospital mortality of acute myocardial infarction in patients with and without renal dysfunction

Authors

  • Abdul Rehman Abid
  • Muhammad Tahir Mohyuddin
  • Liaqat Ali
  • Muhammad Shahid Naveed
  • Nadeem Hayat Mallick

DOI:

https://doi.org/10.21649/akemu.v11i3.1011

Keywords:

Hospital Mortality. Myocardial Infarction. Logistic Models. Angina, Unstable. Prognosis. Shock, Cardiogenic. Creatinine. Angioplasty, Transluminal, Percutaneous Coronary. Comorbidity.

Abstract

Objective: To compare in-hospital mortality of acute myocardial Infarction in patients having normal renal functions with renal dysfunction patients. Setting: Emergency ward, Coronary care units and cardiology wards of the Punjab Institute of Cardiology Lahore. Study design: It was a comparative study. Sample size: 1000 consecutive patients presenting with acute myocardial infarction admitted to the Punjab Institute of cardiology Lahore were studied from 1st March 2004 to 15th August 2004. Results: After fulfilling the inclusion criteria 1000 patients were studied. The mean age of the study population was 60.8+9.38 years. Total number of males in the study population was 642(64.2%) while female patients were 358(35.8%). Patients with any degree of renal dysfunction, except those with end-stage renal disease were more likely to present with anterior MI than were patients without renal dysfunction. Patients with end-stage renal disease and more severe renal dysfunction were more likely to develop heart failure during hospitalization, to experience atrial fibrillation, and to have mechanical complications. Streptokinase therapy was used less frequently in patients with any degree of renal dysfunction than in patients without renal dysfunction, despite a similar incidence of MI. In-hospital mortality was 51(12%) in Group I patients, 46(16.6%) in Group II patients, 36(22%) in Group III patients, 35(27.7%) in Group IV patients and 5(35.7%) in Group V patients with a p value of <0.0001. Severe renal insufficiency had the maximum in-hospital mortality with OR of 5.4 and 95% confidence interval of 2.9-10.3 followed by end stage renal disease OR 5.1 (CI 2.2-12.1), moderate renal insufficiency OR 4.1 (CI 2.3-7.2) and mild renal insufficiency OR 1.9(CI 1.1-3.1) with a p value of <0.0001. Similarly congestive heart failure during hospital stay was observed in 20(4.7%) patients in Group I, 17(6.1%) patients in Group II, 15(9.4%) patients in Group III, 16(12.6%) patients in Group IV and 4(28.6%) patients in Group V. Similar trends were observed in mechanical complications and post myocardial arrhythmias in the study population, Conclusion: Patients with renal dysfunction who have acute MI are a high-risk population and suffer from increased mortality once they are admitted to the hospital. This is because of presence of more risk factors in this sub set of patients.

Published

2016-04-16

How to Cite

Abid, A. R., Mohyuddin, M. T., Ali, L., Naveed, M. S., & Mallick, N. H. (2016). In-hospital mortality of acute myocardial infarction in patients with and without renal dysfunction. Annals of King Edward Medical University, 11(3). https://doi.org/10.21649/akemu.v11i3.1011

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