Teratogenic Nephrotoxicity induced by aluminium

Abstract

The intensified growth of the modern industry has been accompanied by an increased utilization of metals in the processing of manufactured goods, foods and drugs. The mobilization of many trace elements has resulted in a growing concern about the effects of these substances on various biological processes especially about their possible effects on early mammalian development Hardness of drinking water has positively been correlated to lethal congenital malformations. Chemical agents and pharmaceutical drugs play a very important role in the teratogenesis. Amongst other trace elements or environmental chemicals, aluminium has been reported to have teratogenic properties in chick and rats. So the present study was carried out to establish the role of aluminium containing compounds in producing intra-uterine growth retardation and defected renal development, when the pregnant mothers use these compounds for various periods during pregnancy.