Incidence of Hyperuricemia in Patients of Renal Calculi and Their Comparison with Chemical Analysis of Renal Stones
Introduction: The targeted medical prophylaxis required reliable information on stone type which when combined with relevant blood and urine analysis allows identification of treatable risk factors.
Objective: The exact determination of the compositional structure of the renal stone enables the classification of the disease and its subsequent treatment.
Methods: A total of 50 consecutive patients both male and females with upper urinary tract calculi will be included in this study. This is a comparative study between the patients and age matched controls. These patients and controls will have preoperative assessment of serum uric acid. After surgery the chemical examination of stones will be done by Merck kit.
Results: The mean serum uric acid in S.F (3.91 ± .87 mg/dl) was greater than N.S.F (3.79 ± .78 mg/dl) and the difference was statistically not significant. Eight stones (16%), were pure calcium oxalate, while the rest of stones were of mixed variety. Calcium was found in all the 50 (100%) stones,oxalate in 45 (90%). Urates were present in 30 (60%) cases and no pure uric acid stone was found. Phosphate were also present in 5 (10%) cases. Ammonium was present in 7 (15%) stones in mixed form. Magnesium was present in only 2 (5%) stones.
Conclusion: The mean serum uric acid level in Stone Formers was greater than Non Stone Formers but the difference was statistically not significant. Therefore serum uric acid in our study is not a predisposing cause in renal stone formation. It is concluded that most of the stones (84%) were of the mixed variety and calcium oxalate urates and phosphates were the predominant constituents.
Key Words: Hyperuricemia, calcium oxalate, urates.
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