Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

Abstract

Abstract

A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.

Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were

processed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.

Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.

Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.

Abstract

A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.

Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were

processed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.

Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.

Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.

Keywords:  Dyslipidemia, lipid profile, subclinical hypothyroidism.