The Role of hCG in Recurrent Abortion

Abstract

The prospective study carried out in obstetrics and gynecology department of Jinnah Hospital, Lahore from March 1996 to March 1997. The selected 23 patients with history of recurrent abortion and with menstrual gestation less than 8 weeks were included in the study. The patients were evaluated in detail for the cause of recurrent abortion. 15 patients were treated with human chorionic gonadotrophin hormone administered intramuscularly. An initial dosage of 10,000 LU hCG was given, dosage of twice weekly upto 12 weeks and then once weekly uptill 16 weeks. Antenatal care was given and the patients were followed and watch for complications arising in pregnancy and in specific to the treatment. En group I out of 15 patients, 12 patients (le. 80% patients) continued pregnancy while 3 patients (i.e. 20% patients) aborted at 10-14 weeks of gestation. No specific treatment related complications were seen. In group II 8 patients were included. They were treated with placebo at the same interval as in treatment group. 4 patients (i.e. 50% of patients) continued pregnancy with healthy fetal outcome while 4 patients (i.e. 50% of patients) aborted. These results suggests that hCG should be considered as treatment in selected women with recurrent abortion where other specific causes have been ruled out and a potentially treatable hormonal imbalance surmised.