Control Of Heart Rate Changes With Esmolol During Tracheal Intubation In Normotensive And Hypertensive Patients.

Abstract

This is a prospective study of 75 patients conducted at Mayo Hospital, Lahore between 1994-95. Of these patients 37 were male and 38 female. They were divided into three groups of 25 patients each. First group comprised of control group, second normotensive and third hypertensive patients. Response of these patients to tracheal intubation in terms of heart rate was determined and that after Esmolol 100mg I.V bolus 2 minutes before intubation. Response was evaluated immediately, 5 minutes and 15 minutes after intubation. Mean basal heart rate in all three groups showed no significance difference. At 5 minutes control group had highest heart rate among three groups. And this was statistically significant (P=0.01). Difference in mean 5 minutes heart rate between normotensive and hypertensive was not significant. Fifteen minutes recording showed a higher heart rate for control group compared to normotensive. However, difference between control and hypertensive and normotensive versus hypertensive was not significant. Mean basal heart rate in control group increased by 16 beats per minutes at 5 minutes (P<0.01). At 15 minutes heart dropped by 12 beats below 5 minutes rate (P<.05). Difference between basal and 15 minutes was not significant (P=.49). Basal heart rate increased by 2 beats per minute in 0-5 minutes, between 5-15 heart rate decreased by 8 beats per minute which were significant (P-0.01), while difference in basal and 15 minutes was not significant. In hypertensive group difference in basal 5 and 15 minutes was not significant. Therefore while control group showed increased heart rate at 5 minutes, no such significant rise was seen in other two groups. Both the control and hypertensive groups had significant reduction in heart rate at 5 and 15 minutes which was not the case with hypertensive group which showed no significant heart rate response over basal readings.