Anti- Convulsive Effect of Beta Blockers: Antagonism of Strychnine Toxicity.
DOI:
https://doi.org/10.21649/akemu.v4i3.3841Keywords:
Beta adrenergic, blocking agents, drug induced convulsion, central nervous system anti-convulsants.Abstract
Anti convulsive property possessed by Beta Adrenergic Blocking agent against drug induced convulsions was studied, in the Department of Experimental Pharmacology. White mice were used as experimental animals. Strychnine Hydrochloride was Injected intra peritoneally in preliminary experiments and the strychnine LD 100 was determined. One group (n=6) served as control, whereas four other groups (n=6) were pre-treated with Propranolol, Timolol, Atenolol and Labetalol, in a dose of 40 mg/kg subcuntaneously, 30 minutes before strychnine injection. The protective effect of Propranolol was marked timolol and Atenolol did not exhibit anti-convulsive activity. Labetalol, had a worsening effect on the convulsive state; which could be due to its additional a1- receptor blocking activity.Downloads
Published
09/02/2020
How to Cite
CHUGHTAI, R. S. ., HASSAN, S. ., MALIK, N. A. ., & MALIK, M. T. . (2020). Anti- Convulsive Effect of Beta Blockers: Antagonism of Strychnine Toxicity. Annals of King Edward Medical University, 4(3), 13–15. https://doi.org/10.21649/akemu.v4i3.3841
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