A Cross Sectional Study to Compare the Specificity of Creatine Kinase – MB (CK – MB), Cardiac Troponin T (CTnT) and Cardiac Troponin I (CTnI) to Rule in Acute Myocardial Infarction

A Cross Sectional Study to Compare the Specificity of Creatine Kinase – MB (CK – MB), Cardiac Troponin T (CTnT) and Cardiac Troponin I (CTnI) to Rule in Acute Myocardial Infarction

Authors

  • Muhammad Shafiq
  • Muhammad Akram

DOI:

https://doi.org/10.21649/akemu.v18i3.421

Abstract

Background:  Distinguishing whether a patient pre-senting with chest pain has acute myocardial infarction (AMI) or non-cardiac problem is at times difficult. Ruling out AMI requires a test with high diagnostic sensitivity, whereas ruling in AMI requires a test with high diagnostic specificity. This study was planned with the aims and objectives to find out the better mar-ker for the identification of acute myocardial infarc-tion.

Methods:  The study population consisted of 70 pati-ents. Patients from both sexes, with clinical history of typical chest pain for more than 30 minutes in duration with evidence of acute changes of myocardial infarct-ion on ECG were included in the study. This study was conducted to compare the sensitivity of creatine kina-se – MB (CK – MB), cardiac troponin T (CTnT) and cardiac troponin I (CTnI) for detection of AMI. Data analysis was performed with Statistical Package for Social Sciences 11.5 (SPSS 11.5).

Results:  The sensitivity of CK – MB was 100% and 17.78% as compared to CTnT and CTnI respectively. The sensitivity of CTnT was 46.67% and 38.10% as compared to CK-MB and CTnI respectively while the sensitivity of CTnI was100% as compared to both
CK – MB and CTnT.

Conclusion:  It is concluded that CTnI is the pre-ferred, dependable and cost effective serum markers for detection of AMI as compared to CTnT and CK-MB.

 

Keywords:  Acute myocardial infarction (AMI), crea-tine kinase – MB (CK – MB), cardiac troponin T (CTnT) and cardiac troponin I (CTnI).

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How to Cite

Shafiq, M., & Akram, M. (2013). A Cross Sectional Study to Compare the Specificity of Creatine Kinase – MB (CK – MB), Cardiac Troponin T (CTnT) and Cardiac Troponin I (CTnI) to Rule in Acute Myocardial Infarction. Annals of King Edward Medical University, 18(3), 305. https://doi.org/10.21649/akemu.v18i3.421

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