Effect of Olive Oil and Corn Oil (% Induced Hyperlipidemia State) in Aorta and Coronary Arteries of Albino Rats

Abstract

Background:  The role of different oils play an important role for the development of atherosclerosis, and hyperlipidemia which is defined as an elevation of plasma lipids which include high level of plasma LDL. The low serum HDL is a powerful risk factor in CHD. The relation ship between the LDL and HDL in the development of CVD is of interest. The level of cholesterol fraction and the changes in aorta and coronary arteries are compared with control and experimental groups in this study.

Methods:  48 albino rats of 32 week age, including equal number of male & female were kept at optimum atmospheric and hygienic conditions with food and water available at all times. A ventral mid line abdomino-thoracic incision was made after replacing the albino rats in the ether till death. Heart and aorta was then dissected out and biopsy specimen were kept in labeled jar  for fixation, containing formaline and formal calcium.

Results:  A total 48, 32 weeks albino rats were studied for atheromatus changes in aorta and coronaries. The changes of control and experimental groups were compared.

Conclusion:  The current study shows that the groups which was given olive oil showed less atheromatus lesions as compare to the groups with corn oil. Thus olive oil has more beneficial potential then corn oil, and at least, it can be recommended for the high risk patients of ischemic heart disease.