Early Visual Recovery in Patients with Diabetic Macular Edema After Giving Intra-vitreal Injection Avastin and Posterior Subtenon Triamcinolone

Abstract

Objective: To determine the combine role of intravitreal injection Avastin and Posterior subtenon triamcinolone. Methodology: This prospective-randomized control trial study was conducted at Civil hospital Karachi, Pakistan from January 2019 to October 2019. Ethical approval of the study was taken from Review Board of Baqai hospital of Diabetology and Endocrinology. Subject were categorized into two study group; Group A was treated with combine treatment of intravitreal injection Avastin and Posterior subtenon triamcinolone. Group B was treated with intravitreal injection Avastin only. The changes in BCVA (best corrected visual acuity), IOP (intraocular pressure) and CMT (central macular thickness) were compared between the two groups. Results In group A 42 (50.6%) were included and treated with combine treatment of intravitreal injection Avastin and Posterior subtenon triamcinolone. Whereas, in group B 41 (49.4%) were treated with intravitreal injection Avastin only. In group A gender male, hypertension, smoking shows significant results as compared to group B. Baseline and follow up characteristics (BCVA, CMT, IOP and change in RNFL) of group A shown statistically significant, while (BCVA, CMT and change in RNFL) were found significant in group B. Conclusion: The outcome of this study revealed that combine intravitreal injection Avastin and Posterior subtenon triamcinolone in DME induced earlier visual recovery and decreased CMT noted.