Correlation between Ki-67 index and Her-2 Expression Status in Invasive Ductal Carcinoma of Breast

Abstract

Background: Ki-67 index has been used to categorize primary infiltrating breast carcinoma into their surrogate molecular subtypes for selection of treatment strategies. HER-2 also serves as basis for molecular classification of breast cancer and patients having positive expression of HER-2/neu have been selected for anti-Her-2 therapy and have a better prognosis. In this article, we learn about 10 pictures to find the association of Ki-67 index and expression status of HER-2 in primary breast ductal carcinoma of infiltrating type. This correlation may improve insight into the prognosis of invasive ductal breast cancer and also play a vital role in therapeutic management of patients. Methods: 143 primary ductal breast carcinoma cases having infiltrating type were analyzed at Pathology department in Fatimah Jinnah Medical University, Lahore between April 2019 and January 2020. All patients diagnosed on Tru-Cut/core, wedge biopsies and mastectomy specimens were included. Evaluation of Her-2 status and Ki-67 index was carried out by immunohistochemistry after routine formalin fixation and paraffin embedding of sections from tumor area. Results: High index of Ki-67 was observed (> 14 %) in 74 cases (51.4%) and low (≤ 14%) in the remaining 69 (49.6%) cases. 79 cases (55.2%) were Her-2 positive and 64 cases (44.8%) were Her-2 negative. A significant (p value < 0.05) relationship was demonstrated between higher Ki-67 index and positive Her-2 expression. Conclusion: This study concluded that strongly significant association is exists among high index of Ki-67 and positive Her-2 expression status.