Effect of Preoperative Chemotherapy in Reduction of Tumor Volume in Wilms Tumor in Relation to Histology

Effect of Preoperative Chemotherapy in Reduction of Tumor Volume in Wilms Tumor in Relation to Histology

Authors

  • Saadia Anwar The Children's Hospital & University of Child Health Sciences Lahore
  • Maria Saeed Department of Pediatric Hematology Oncology &BMT, The Children's Hospital and ICH,Lahore,Pakistan
  • Mahwish Faizan Department of Pediatric Hematology Oncology &BMT, The Children's Hospital and ICH,Lahore,Pakistan
  • Ahmed Imran Department of Pediatric Radiology, The Children's Hospital &ICH,Lahore,Pakistan
  • Samina Zaman Department of Pediatric Histopathology, The Children's Hospital & ICH,Lahore,Pakistan
  • Muhammad Saleem Department of Pediatric Surgery, The Children's Hospital And ICH,Lahore,Pakistan

DOI:

https://doi.org/10.21649/akemu.v30i1.5245

Keywords:

Wilms Tumor, Histology, Pre-operative chemotherapy, Tumor Volume.

Abstract

Background: Wilms tumor (WT) is the most common renal tumor in children under5 years. The survival rates of children with Wilms tumor have improved dramatically over a few decades. Objective: To find out the effect of preoperative chemotherapy in the reduction of tumor volume in Wilms tumor and its correlation with tumor histology.

Methodology: A total of 53 patients diagnosed with WT under 15 years were enrolled. After a complete history and physical examination, all information including demographics, metastatic status, pre and post-chemotherapy volume, histology, postop stage and surgical complication was collected and entered on Performa. All patients received neo-adjuvant chemotherapy according to the SIOP protocol. Data was entered and analyzed in SPSS 23.

Results: Fifty-three patients were included. There were 33 (62.3%) male and the mean age was 4.45 +2.2 years. Thirty-two (60.4%) children had localized disease and13 (24.5%) children had lung metastasis. There was a significant reduction of tumor volume of >500ml in 8(15.1%) patients after preoperative chemotherapy and the majority 18(34 %) patients had 100-200 ml decrease in tumor volume. Intermediate risk histology 40 (75%) was most prevalent. During surgery, 35 (66%) children had no complications .Thirty-nine (73.5%) patients were cured, 4 (7.5%) patients were expired and 5 (9.4%) got left against medical advice (LAMA).

Conclusion: Our study infers that pre-operative chemotherapy reduces the tumor volume remarkably in WT making resection feasible

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Published

03/28/2024

How to Cite

Anwar, S., Saeed, M., Faizan, M. ., Imran, A., Zaman, S. ., & Saleem, M. (2024). Effect of Preoperative Chemotherapy in Reduction of Tumor Volume in Wilms Tumor in Relation to Histology. Annals of King Edward Medical University, 30(1), 6–11. https://doi.org/10.21649/akemu.v30i1.5245

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Research Articles

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