Cardio-Hepatic Interactions in Acute Heart Failure: A Study on Liver Function Test Abnormalities
DOI:
https://doi.org/10.21649/akemu.v31i1.5759Keywords:
Liver function tests, Acute heart failure, Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase.Abstract
Background: While chronic heart failure impacts liver function, Acute heart failure's (AHF) effect remains unclear. This study investigates the prevalence and clinical significance of abnormal liver function tests (LFTs) in AHF patients.
Objective: To determine the prevalence of abnormal LFTs in patients with AHF and to examine the association between AHF severity and LFTs abnormalities' prevalence.
Methods: A cross-sectional study was conducted at the Gulab Devi Hospital Lahore, from June 26, 2023, to December 26, 2023. 100 diagnosed AHF patients were selected using a non-probability selection technique. Blood samples were processed in the Pathology lab of Gulab Devi Educational Complex. Data were analyzed using SPSS 26, with Chi-Square tests for associations and Cramer's V for significant results to measure association strength.
Results: In our study of 100 diagnosed cases of AHF, 56% were males and 44% were females. Most patients exhibited abnormal LFTs, with elevated levels of ALT, AST, ALP, and total bilirubin observed in 56%, 55%, 95%, and 37% of cases, respectively. Notably, 70% of patients had hypertension, 54% had diabetes, and 25% of patients smoked as additional risk factors. Our research found that these factors had less of an impact on abnormal LFTs, even though they seemed to be associated with an incidence of AHF.
Conclusion: A notable prevalence of abnormal LFTs was observed in AHF and those diagnosed with AHF had a higher chance of acquiring hepatic disease and hepatic dysfunction.
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