VARIATION IN REGIONAL DISTRIBUTION OF MULTIPLE SCLEROSIS PLAQUES IN PAKISTANI AND CANADADIAN NATION

Abstract

Abstract

Background and Purpose:  To determine retrospec-tively the variation in regional involvement of brain among established cases of MS Canadian and Pakis-tani nation. We also analyzed parahippocampal gyrus lesions with further characterization according to grey white matter distribution.

Methods:  Sixty patients presenting clinically with multiple sclerosis were included as two groups of thir-ty each from Canadian and Pakistani nation respect-tively. Imaging was performed on 1.5 T MR system acquiring T₁W, T₂W, Proton density, FLAIR and T₁W post gadolinium sequences. Lesions were counted and classified according to anatomic regions paraventri-cular, temporal lobe and juxtacortical. The juxtacorti-cal involvement of parahippocampal region consider-ing brain parenchymal involvement were classified.

Zaidi N.R.¹

Former Professor of Radiology

KEMU / Mayo Hospital, Lahore

Ahmad M.W.²

Medical Officer

Department of Radiology, Mayo Hospital, Lahore

Mehboob R.³

Assistant Professor Department of Pathology

King Edward Medical University, Lahore

Results:  Canadians haved more disease load as com-pare to Pakistani nation. Mean age of the patients are relatively younger in Canadians however anatomical lesional distribution in temporal lobe, paraventricular and parahippocampal region more or less same.

Conclusion:  Multiple sclerosis is more common amo-ng Canadian however its lesional anatomical distri-bution including parahippocampal region had no sig-nificant variation.

Keywords:  Multiple sclerosis (MS), Periventricular (PVC), Temporal lobe, Juxtacortical (JC) and Para-hippocampal.