Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Authors

  • Muhammad Khalid Ch
  • Muhammad Saqib Saeed
  • Rizwan Iqbal
  • Akhtar Ali

DOI:

https://doi.org/10.21649/akemu.v22i1.803

Keywords:

Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

Abstract

Abstract

Background:  Tuberculous pleurisy is a common extrapulmonary manifestation and is second to tuberculous lymphadenitis. Due to its paucibacillary in origin, its diagnosis is a challenge. Furthermore, it is also complicated by the emergence of MDR. Gene Xpert MTB/RIF is a new rapid promising innovation for the detection of mycobacterium tuberculosis and its resistance to Rifampicin, giving result within two hours.

Objective:  To evaluate the diagnostic role of Gene Xpert MTB/RIF in suspected cases of tuberculous pleurisy.

Study Design:  Cross sectional study.

Study Setting:  Institute of Chest Medicine Mayo Hospital – a Tertiary Care Hospital affiliated with King Edward Medical University, Lahore.

Methodology:  The study group, one hundred (M-60 and F-40) cases having exudative, predominantly lymphocytic pleural effusion with strong suspicion of tuberculous in origin were enrolled randomly for Gene Xpert MTB / RIF.

Results:  Among one hundred study cases, Gene Xpert detected mycobacterium tuberculosis in 12(12%) cases [M-8 (13.3%) and F-4 (10%)]. Resistance to Rifampacin was detected in 6 (6%) cases [M-2 (3.3%) and F-4 (10%)].

Conclusion:  Gene Xpert MTB/RIF is a useful new rapid promising technique to diagnose tuberculous pleurisy. Although at present it has limited availability and utility.

Key Words:  Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

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Published

02/13/2016

How to Cite

Ch, M. K., Saeed, M. S., Iqbal, R., & Ali, A. (2016). Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy. Annals of King Edward Medical University, 22(1), 78. https://doi.org/10.21649/akemu.v22i1.803

Issue

Vol. 22 No. 1 (2016): AKEMU

Section

Medicine & Allied

License

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments publications@kemu.edu.pk

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