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</xml><![endif]--> <!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} --> <!--[endif]--> <p class="MsoNormal" style="margin-bottom: 4pt; text-align: justify;"><strong><em><span style="font-size: 10pt; color: black;">Objectives:  </span></em></strong><span style="font-size: 10pt; color: black;">To find the effects of diclofenac and dobutamine during myocardial ischaemia.</span></p> <p class="MsoNormal" style="margin-bottom: 4pt; text-align: justify;"><strong><em><span style="font-size: 10pt; color: black;">Methods:  </span></em></strong><span style="font-size: 10pt; color: black;">The project has been designed to find out the individual and combined effects of diclofenac and dobutamine on the cardiovascular functions[Heart Rate, Blood Pressure<span>  </span>and Coronary Blood Flow] and ECG Parameters (QRS complex, R wave and T wave) in the pentobarbitone anesthetized rabbits before and after coronary occlusion. </span></p> <p class="MsoNormal" style="margin-bottom: 4pt; text-align: justify;"><strong><em><span style="font-size: 10pt; color: black;">Results:  </span></em></strong><span style="font-size: 10pt; color: black;">Diclofenac in the dosage of (500-750ug/kg/min) has stimulant effect on normal heart rate while after coronary occlusion heart rate is significantly suppressed with diclofenac in the dosage of (500-1000ug/kg/min). Moreover diclofenac resulted into suppression of normal blood pressure. After coronary occlusion the combined effect of diclofenac and dobuta-mine resulted into suppression of heart rate though not significant statistically. Diclofenac in the dosage of (250-1000ug/kg/ min) results into significant increase in the normal amplitude of R wave while T wave remains unaffected. Diclofenac with dobutamine after coronary occlusion also leads to significant widening of QRS complex.</span></p> <p class="MsoNormal" style="margin-bottom: 4pt; text-align: justify;"><strong><em><span style="font-size: 10pt; color: black;">Conclusion:  </span></em></strong><span style="font-size: 10pt; color: black;">Diclofenac alone and with dobutamine after coronary occlusion not only slows down heart rate but also aggra-vates myocardial ischaemia.</span></p> <p class="MsoNormal" style="text-align: justify;"><strong><span style="font-size: 10pt; color: black;">Key Words:  </span></strong><span style="font-size: 10pt; color: black;">Myocardial ischaemia (MI), NSAIDs, Coronary occlusion (C.O), Heart Rate (H.R), Mean Arterial Pressure (MAP), Blood Pressure (B.P).<strong></strong></span></p>}, number={3}, journal={Annals of King Edward Medical University}, author={Bhatti, Abdul Shabbir Ali and Zahid, Muhammad and Khan, Abdul Hameed}, year={2010}, month={Feb.}, pages={110} }