@article{Ijaz_Yasmin_Bhatti_2012, title={Relationship of B-vitamins (Vitamin B12, B6 and Folic Acid) and Coronary Artery Disease in Pakistan}, volume={17}, url={https://annalskemu.org/journal/index.php/annals/article/view/580}, DOI={10.21649/akemu.v17i4.580}, abstractNote={<p><strong>Abstract</strong></p> <p><strong>Background:  </strong>Coronary artery disease is one of the most lethal diseases in Pakistani population and vita-min deficiency is common in this country.</p> <p><strong>Aim:</strong>  Present study was carried out to find a probable relationship between vitamin B<sub>12</sub>, B<sub>6</sub> and Folic acid and coronary artery disease in Pakistani population.</p> <p><strong>Methodology:</strong>  A cross sectional study was carried out. A total of 40, angiographically diagnosed male patients of coronary artery disease, between 30 - 45 years of age were taken as cases. A same number of age, sex and socioeconomically matched normal heal-thy male subjects with normal carotid doppler study were taken as controls. Fasting venous blood was obta-ined from all the cases and controls in E.D.T.A vacu-tainers. Plasma was analyzed for vitamin B<sub>12</sub> and folic acid levels using competitive protein binding radio-assay and for vitamin B<sub>6</sub> (PLP, a co-enzymic form of vitamin B<sub>6</sub>) using radioenzymatic assay.</p><p><strong>Results:  </strong>Mean plasma vitamin B<sub>12</sub> concentration in coronary artery disease patients was found to be lower than the mean for controls (150.25 ± 135.98 pmol/L vs 204 ± 92.26 pmol/L). Plasma folic acid levels were also lower in patients than in the controls (12.11 ± 17.35 nmol/L vs 28.47 ± 37.23 nmol/L). The levels of vitamin B<sub>6</sub> were also low in patients than in controls (8.26 ± 6.18 nmol/L vs 11.82 ± 9.24 nmol/L).The results also showed an inverse relation between the vitamin B<sub>12</sub>, B<sub>6</sub> and folic acid levels and the extent of coronary artery disease as shown by the number of coronary blood vessels blocked.</p><p><strong>Conclusion:</strong>  There is an inverse relationship between the plasma vitamin levels and coronary artery disease. It may therefore be concluded that the deficiency of B-vitamins (B<sub>12</sub>, B<sub>6</sub> and folic acid) may be aggravating the risk of coronary artery disease through an interplay with the classical risk factors of coronary artery disease.</p>}, number={4}, journal={Annals of King Edward Medical University}, author={Ijaz, Rahila and Yasmin, Riffat and Bhatti, Sarwar}, year={2012}, month={Nov.}, pages={428} }