TY - JOUR PY - 2017/12/05 Y2 - 2024/03/28 TI - Hypoglycaemic Effect of Turmeric in Alloxan-Induced Diabetic Rats JF - Annals of King Edward Medical University JA - Annals KEMU VL - 23 IS - 3 SE - Articles DO - 10.21649/akemu.v23i3.2011 UR - https://annalskemu.org/journal/index.php/annals/article/view/2011 SP - AB - <p>Background: Diabetes Mellitus is a syndrome of persistent hyperglycaemia, caused by absolute or&nbsp;relative deficiency of insulin. Diabetes is an advancing disease if uncontrolled and can lead to various&nbsp;macrovascular and microvascular compli-cations. Alloxan, a pyrimidine derivative is a potent&nbsp;diabetogenic agent used to develop type-I diabetes in animal models. Turmeric (Curcuma Longa) is a&nbsp;medicinal plant having antioxidant properties.<br>Objective: To determine hypoglycaemic effect of turmeric in diabetic rats and to compare serum glucose&nbsp;levels among groups.<br>Methodology: In this study alloxan (intraperito-neal, 150mg/kg body weight) was used to produce&nbsp;animal models of type-I diabetes. An experimental animal study was conducted on forty five albino rats.&nbsp;Animals were divided into three groups with fifteen animals each (normal control group A, diabetic&nbsp;untreated group B and diabetic group C treated with turmeric powder).Turmeric was given daily orally&nbsp;through 5cc disposable syringe (oral gavage method)in a dosage of 300mg/kg body-wt. dissolved in 4 ml&nbsp;distilled water per rat to all the 15 group C diabetic albino rats following one week after induction of&nbsp;diabetes.&nbsp;Blood samples of animals were taken from saphenous vein after overnight fasting at zero day (one&nbsp;week following induction of diabetes in groups B and C), by the end of 8th week and by the end of 12th&nbsp;week respectively. Commercially available Human kits were used to find out serum glucose levels by&nbsp;glucose oxidase method. Analysis of data was done by using SPSS version 18.0.<br>Results: Significantly elevated levels of serum glucose were found after alloxan administration.&nbsp;Administration of turmeric in dosage of 300mg/kg body weight for 12 weeks to group C diabetic animals&nbsp;showed significant improvements in serum glucose levels towards normal.<br>Conclusion: Turmeric powder possesses hypoglycemic effects.</p> ER -