TY - JOUR AU - Muhammad Arshad Khan, AU - Ali Asad Khan, AU - Yasir Shafi, AU - Faisal Masood, AU - Sidrah Lodhi, AU - Sajid Abaidullah, PY - 2019/12/30 Y2 - 2024/03/28 TI - Correlation Between Alanine Aminotransferase and Left Ventricular Mass in Patients with Non-Alcoholic Fatty Liver Disease JF - Annals of King Edward Medical University JA - Annals KEMU VL - 25 IS - 4 SE - Articles DO - 10.21649/akemu.v25i4.3126 UR - https://annalskemu.org/journal/index.php/annals/article/view/3126 SP - AB - <p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for chronic kidney disease, endocrinopathies, cardiovascular disease (CVD), cerebrovascular disease and osteoporosis. Many prospective follow-up studies demonstrated cardiovascular mortality as an important cause of death in these patients. However, the exact relationship between ALT and CVD especially LVH is undetermined.</p><p><strong>Objective: </strong>The objective of this study was to determine the correlation between raised ALT levels and left ventricular mass (LVM) in NAFLD patients.</p><p><strong>Methods: </strong>In this cross sectional analytical study, 115 patients (both male and female) were selected through non-probability purposive sampling technique after meeting inclusion and exclusion criteria. These patients, aged 20-60 years, were diagnosed cases of NAFLD with transaminitis (ALT ≥40 unit/L). Venous samples were collected for ALT, viral serology and fasting lipid profile. All the patients underwent ultrasound abdomen and echocardiography for LVM.</p><p><strong>Results: </strong>Mean age of patients was 44.63±1.03 while gender distribution showed 55(47.8%) male and 60(52.2%) female patients with a mean body mass index (BMI) of 26.75±5.048. Mean ALT level was 56.68±9.08 and mean LVM was 190.60±14.23 grams. Correlation coefficient for ALT and LVM was 0.571 which showed moderate correlation between these two parameters. A positive moderate correlation existed between ALT and LVM after stratifying the data according to age, gender and BMI.</p><p><strong>Conclusion: </strong>Elevated ALT levels in NAFLD patients can serve as a screening tool for cardiovascular risk assessment. Whether there is a temporal relationship between transaminitis and an increased risk of cardiovascular events needs further statistical evidence.</p> ER -