TY - JOUR AU - Jabbar, Abdul AU - Nazir, Abira AU - Khalil, Javed AU - Ansari, Naveed Iqbal AU - Qureshi, Khalid Mahmood AU - Javed, Farooq PY - 2013/05/30 Y2 - 2024/03/28 TI - To Compare the Effects of Tribulus Terristris with Furosemide on Urine Volume and Electrolytes JF - Annals of King Edward Medical University JA - Annals KEMU VL - 18 IS - 2 SE - Articles DO - 10.21649/akemu.v18i2.400 UR - https://annalskemu.org/journal/index.php/annals/article/view/400 SP - 196 AB - <p class="MsoNormal" style="margin-bottom: 1.8pt; text-align: justify; tab-stops: 18.0pt;"><strong><span style="font-size: 11pt;">Background:&nbsp;&nbsp;</span></strong><span style="font-size: 11pt;">Tribulus terristris belongs to Zygo-phayllaceae family,</span><span style="font-size: 11pt;"> although the plant was recognized as a diuretic and aphrodisiac but, its efficacy as diu-retic has never been evaluated. The objective of this study was to evaluate and compare its effect on urine volume and electrolytes with furosemide. It is a Com-parative study.</span></p> <p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><strong><span style="font-size: 11pt;">Material and Methods:</span></strong><span style="font-size: 11pt;">&nbsp;&nbsp;The<strong> </strong>study was conducted in&nbsp;</span><span style="font-size: 11pt;">the department of Pharmacology and Therapeutics, Post Graduate Medical Institute, Lahore. The duration of study was two weeks. Twenty Four rabbits of mixed breed were purchased locally and kept in the animal house of Postgraduate Medical Institute, Lahore for a week for acclimatization before starting the experi-ment. Twelve hours light and dark cycle was main-tained. They were fed on grass, grain, seasonal vege-tables and water adlibitum. Animals were weighed for calculation of dosage of herb. They were divided into three equal groups randomly. Group Tt was given Tt while Group F was given furosemide, while group C was not given any drug.</span></p><p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><strong><span style="font-size: 11pt;">Results:&nbsp;&nbsp;</span></strong><span style="font-size: 11pt;">(Tt vs F), the change in 24 hours urine volume was found statistically significant P &lt; 0.05 on day 01 and day 15. Serum Na+, K+ levels were also found statistically significant P &lt; 0.05 throughout the study period.</span></p><p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><strong><span style="font-size: 11pt;">Conclusion:&nbsp;&nbsp;</span></strong><span style="font-size: 11pt;">The results of our study reveal that Tt has diuretic properties but is less efficacious than furosemide. Keeping in view, the result of our study, we recommend that the use of this herb may be promoted as diuretic agent, it may be helpful in pulmonary oedema and other oedematous conditions.</span></p><p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><strong><span style="font-size: 11pt;">Key words:</span></strong><span style="font-size: 11pt;">&nbsp;&nbsp;Control = CT. Tribulus terristris = Tt. Furosemide = F. Versus = VS. Sodium = Na+. Potassium = K+.</span></p><p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><span style="font-size: 11pt;">&nbsp;</span></p><p class="MsoNormal" style="text-align: justify; tab-stops: 18.0pt;"><span style="font-size: 11pt;"> <!--[if !supportLineBreakNewLine]--><br /> <!--[endif]--></span></p> ER -