Statistical analysis of astrocytic glioma

Abstract

Fifty patients of both sexes of Astrocytic Glioma from Sheikh Zayed Hospital and Lahore General Hospital Lahore were included in this study. Ten normal brain tissues (control) were taken from accident cases. Out of 50 study cases there were 16 (32%) were low grade (I-II) Astrocytic Glioma and 34 (68%) were high grade Astrocytic Glioma. The male to female percentage was found out to be 26 (52%) and 24 (48%) respectively. Among the males, 11 (22%) were in grade I-II while 15 (30 %) were in grade III-IV Astrocytic Glioma, while 5 (10 %) females were in grade I-II and 19 (38 %) were in grade No statistical sex difference was seen in the ratio of male and female who developed Astrocytic Glioma (P>0.05). The ages of the patients ranged from 10 to 76 years with maximum number of cases in the age group 30-49 years. In this age group, 11 (22%) patients had grade I-II while 20 (40%) were in grade type of Astrocytic Glioma. The statistical difference of age in different groups was found to be highly significant, (P<0.01). The most common presenting complaints were headache, vomiting, weakness of limbs, loss of orientation and giddiness. These were observed mainly in grade III-IV Astrocytic tumors. The complaints of difficulty in speech, papilloedema and fits were observed often with an almost equal ratio in all grades of Astrocytic Glioma. The loss of consciousness was observed only in Grade III-IV tumors. The most common site of Atstorcytic Glioma was Parietal lobe and Fronto-parietal lobe constituting 9 (18%) in grade I-II and 15 (30%) in grade HI-IV Astrocytic Gliomas, that is statistically significant, (P<0.05). The most common site of Astrocytic Glioma was Parietal lobe, 17 out of 50 (7 in grade I-II and 10 in grade III-IV), while the second most common site of this tumor was Temproparietal region, (4 in grade I-II and 6 in grade III-IV). There were 29 Astrocytic Gliomas in right lobe (10 in grade I-II, and 19 in grade III-IV), while 18 in left lobe (5 in grade I-II and 13 in grade III-IV). This was statistically highly significant, (P<0.01). High grade Astrocytic Glioma was also present in Thalamus, mid brain, and Interventricular septum.