To study and compare the effects of aspirin and Nigella Sativa on coagulation profile in Albino Rats for six weeks

Abstract

Ninety albino rats were selected and were divided into six groups on the basis of different diets given. Control group (1) was fed on synthetic diet and experimental groups (11A, 11B, 11C, 11D and 11E) were fed on 1 mg aspirin, 15mg, 30mg, 45mg Nigella Sativa per kg body weight respectively while 11E was given 30 mg NS and 1 mg aspirin/kg body wt. Blood samples were collected by heart puncture and different tests were done. Bleeding time was shortened significantly in groups taking N.S. when compared with control. BT was prolonged in groups taking aspirin only. APTT was reduced significantly in groups taking different concentration of NS when compared with control. Percentage of clot retraction was weak significantly in groups taking aspirin only when comparing with other groups.