An Experimental study of Coagulation Profile in Albino Rats Fed on Canola Oil Supplemented with Atherogenic Element for a period of 6 weeks

Abstract

An experimental study on albino rats was designed to estimate the coagulation parameters like Prothrombin time (PT), Activated Partial Thromboplatin Time (APTT) and fibrinogen level and coagulation parameters were compared in animals fed on low and high cone of canola oil and canola supplemented with atherogenic element. Sixty albino rats were selected and divided into five different groups with twelve rats in each group. Group A was given synthetic diet (control) and other four groups were given low and high cone. of canola oil and canola oil+atherogenic elements for 6 weeks duration. At 6th week blood samples were collected. PT and APTT were reduced in groups taking different cone of canola + atherogenic element when compared with those on pure canola oil. Groups on canola+atherogenic diet showed increased fibrinogen level when comparing with those on pure canola oil for six weeks.