Effect of Subclinical Hypothyroidism on Fasting Serum Low Density Lipoprotein-C and High Density Lipoprotein-C

Abstract

Abstract

Numerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.

Methods:  This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.

Results:  TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be

1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.

Conclusion:  The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C level.

Abstract

Numerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.

Methods:  This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.

Results:  TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be

1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.

Conclusion:  The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C levels.

Key words:  Subclinical hypothyroidism, TSH, HDL-C, LDL-C