Argyrophilic Nuclear Organizer Regions (AgNORs) in Lymphocytic Leukaemia
Keywords:AgNOR, ( Agyrophilic, nuclear organizer regions), nucleus, acute lymphoblastic leukaemia
Nuclear organizer regions code for ribosomal RNA and are associated with non-histone nucleoproteins that can be identified by silver staining (AgNORs). AgNORs have been correlated to proliferative activity of tumours. The present study was carried out to observe the AgNOR pattern in lymphocytic Ieukaemias. A significant increase in AgNOR counts (p<O.OO1) was observed in acute lymphoblastic leukaemia (ALL) patients as compared to normal controls. The proliferative in dcx was found to be significantly higher in ALL. In chronic lymphocytic leukaemia and reactive lymphocytes, AgNOR Pattern was found similar to the normal lymphocytes. These resells suggest that AgNORs counts are significantly higher in acute lymphoblastic leukaemia.
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