Comparison of Argyrophilic Nucleolar Organiser Regions (AgNORS) with Proliferating Cell Nuclear Antigen (PCNA) in Different Grades of Transitional Cell Carcinoma of Urinary Bladder

Authors

  • Abdul Haseeb Khan
  • A S Khan
  • N A Chaudhary
  • M Tayyab

DOI:

https://doi.org/10.21649/akemu.v13i2.97

Abstract

Objective: To Compare Argyrophilic Nucleolar Organiser Regions (AgNORs) pattern with Proliferating nuclear antigen (PCNA) in different grades of transitional cell carcinoma.

Design: Descriptive and Comparative study.

Material and Methods: A total of fifty transurethrally resected bladder tumour samples (TUR BT) were collected from Mayo Hospital, Lahore and Services Hospital, Lahore and processed for H&E, AgNOR stain and PCNA stain. The grading of tumours were made on H&E stain. While AgNOR pattern and PCNA labeling index were recorded for each case.

Results: A significant higher proportion of cases (p<0.02) with 3+ AgNOR dispersion were seen in grade III tumours. The AgNOR proliferative index in grade III tumour was significantly higher (p<0.05) as compared with grade II tumours. The cases with AgNOR dispersion of 3+ had significantly higher mean PCNA labeling index (p<0.02) when compared tumours of 2+ AgNOR dispersion.

Conclusion: AgNOR and PCNA have significant role in grading of transitional cell carcinoma. The demon-stration of AgNOR dispersion is also a simple and cost effective procedure and could be considered as a substitute for PCNA labeling index.

Key words:  Nuclear organizer regions, PCNA, Transitional cell carcinoma.

How to Cite

Khan, A. H., Khan, A. S., Chaudhary, N. A., & Tayyab, M. (1). Comparison of Argyrophilic Nucleolar Organiser Regions (AgNORS) with Proliferating Cell Nuclear Antigen (PCNA) in Different Grades of Transitional Cell Carcinoma of Urinary Bladder. Annals of King Edward Medical University, 13(2). https://doi.org/10.21649/akemu.v13i2.97

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