Histological Aspects of Diazepam Induced Teratogenicity in Rats

Abstract

This study was conducted to determine the teratogenic potential of therapeutic & high dose of diazepam in rats. Histological study of liver & kidney of fetuses was carried out after exposing them to therapeutic dose (0.14 mg per kg body weight) of diazepam intraperitoneally during different periods of gestation and high dose (280 mg per kg body weight) during the period of organogenesis. Rats 140 in number were divided into various groups & subgroups. Adverse effects were noted and compared with controls. In the liver, relative tissue weight index (RTW1) was high, histological evidence of inflammation and mild disturbance of architecture to total disarray was noted. Kidney also showed glomerular and tubular damage. In a dose related manner with an increase in RTWI. We conclude that diazepam is teratogenic in a dose related manner, affecting fetal liver and kidney at cellular level, It should be prescribed during period of organogenesis with caution.