Variations of ABO Blood Groups. Gene Frequencies in the Population of Sindh (Pakistan)

Abstract

The survey was carried out of allelic frequencies of ABO alleles in the population of different cities of Pakistan (Larkana, Jamshoro Hyderabad, Karachi) and in different ethnic groups (Abro, Noohani and schedule cast Hindus). The analysis shows that there is no any constant pattern except the general fashion of blood group distribution i.e. the O group has highest frequency, A and B are in the mid and AB blood group is at least of all. Percentage distribution of ABO and their allelic frequencies are described in the districts/cities of the province of Sindh, Pakistan. Relationship between the distribution of ABO phenotypes and gene frequencies are discussed. A significant decrease in the AB phenotypes is seen in the cities. The average gene frequencies for ABO groups in the population of Sindh are 0.1972 + 0.017, 0.2104 + 0.019, 0.5986 + 0.015, for A, B, O respectively. The average percentage distribution out of total 49061 cases the distribution of blood groups was A = 25.83%, B 28.17%, 0=37.78% and AB = 8.30%.