Clinical Spectrum of Plasmodium Vivax Malaria in Children Presenting to a Tertiary Care Hospital, Lahore


  • Muhammad Rafique
  • Komal Seher
  • Kamran Qureshi
  • Wajiha Rizwan
  • Fouzia Ishaq
  • Shumaila Zia


Malaria, demographics, haematology, Plasmodium Vivax, clinical features, children, Lahore, Pakistan


Background: Malaria is endemic in Pakistan and physicians should be fully aware of varied clinical and laboratory manifestations of malaria in children to maintain high index of suspicion for diagnosis. Objective: To describe the clinical features and haematological investigations of children with Plasmodium Vivax malaria in a tertiary care hospital. Methods: This analytic cross-sectional study consisted of 83 children under15years of age. They had clinical features suggestive of malaria and blood films were positive for Plasmodium Vivax. Data were collected by non-probability convenient sampling technique and were analyzed by SPSS version 21. Results: Of 83 children, mean age was 5.3±4.4 years and 66% were males. All patients had fever (100%) associated with rigor and chills (94%), vomiting (73.5%) and abdominal pain (32.5%). Splenomegaly was found in 92.8%, pallor in 89%, hepatomegaly in 85% and jaundice in 25% children. It was observed that 77.1% of the children had anaemia with mean haemoglobin as 9.1±2.53 g/dL and 84% had thrombocytopenia with mean thrombocyte count as 114 ± 73×103/mm3. Red cell indices and haematocrit were below the normal limits. Splenomegaly was significantly associated with rigors/chills, vomiting, jaundice, abdominal pain and pallor (p <0.05). Hepatomegaly was found to has significant association with abdominal pain only (p <0.001). Conclusion: High grade fever with chills/rigors and vomiting along with hepatosplenomegaly were main clinical features of Plasmodium Vivax malaria. Anaemia and thrombocytopenia were most frequent haematological disturbances.



How to Cite

Rafique, M. ., Seher, K. ., Qureshi, K. ., Rizwan, W. ., Ishaq, F. ., & Zia, S. . (2020). Clinical Spectrum of Plasmodium Vivax Malaria in Children Presenting to a Tertiary Care Hospital, Lahore. Annals of King Edward Medical University, 26(3), 443-449. Retrieved from




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