Total Serum Sialic Acid (TSSA) in Selective Patients of Diabetes Mellitus (DM)

Abstract

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Total serum sialic acid (TSSA) and Fasting Blood Glucose levels were determined in 50 normal and healthy (control) individuals and 100 patients of diabetes mellitus. Diabetic patients were divided into two main groups i.e., with and without retinopathy. An increase in TSSA was found in all diabetic patients. A highly significant relationship of total serum sialic acid was observed in patients with retinopathy where p < 0.01 (p = 0. 0084), whereas no significant relationship of total serum sialic acid with blood glucose could be seen in this study, p > 0.1 (p = 0.186). The data showed a greater increase in TSSA in diabetic patients with retinopathy than those without it, i.e, 2.59 ± 0.47 mM/L (0.81 ± 0.15 G/L) vs 2.02 ± 0.29 mM/L (0.63 ± 0.09 G/L). Whereas, the Fasting Blood Glucose level in diabetic patients with retinopathy was 10.78 ± 0.94 mM/L (1.94 ± 0.17 G/L) and those without it was 9.94 ± 0.78 mM/L (1.79 ± 0.17 G/L) vs 4.83 ± 0.50 mM/L (0.87 ± 0.09 G/L) in the control individuals. Further more, our data also depicted a significant relationship of TSSA with duration of diabetes mellitus and degree of retinopathy and whether it is with or without maculopathy. But, there were non-significant relationships of TSSA with age as well as sex of the patients with p > 0.05 (p = 0.135 & 0.102 respectively).