Correlation Between Non-insulin Dependant Diabetes Mellitus and Serum Sialic Acid

Abstract

Abstract:  Sialic Acid (SA) is a class of important glycemic derivatives that contain 9 carbon atoms.¹ N-acetyl neuraminic acid (NANA) is the principal SA found in human tissues.² SA is a generic term for a family of acetylated derivatives of neuraminic acid and is an essential component of glycoproteins and glycolipids.³ In this study, the relationship between Serum Sialic Acid (SSA) and Non-Insulin Dependant Diabetes Millitus (NIDDM) patients was investigated. One hundred (100) subjects, 32 males and 68 females, were included in the study. They were divided into two groups according to pre-sence or absence of Non-Insulin Dependant Diabetes Mellitus (NIDDM). Group-A was having 24 subjects without Diabetes Mellitus (DM) as a control; whereas, Group-B comprised of 76 patients with NIDDM. Sialic Acid (SA), Glucose, Lipids (Triacylglycerols and Total Cholesterol) levels were measured in serum. While, Glycated Hemoglobin (HbA_1C) level was assayed in whole blood. Here we found a highly significant correlation between NIDDM patients and SSA as, NIDDM Patients had higher levels of SSA 2.37 ± 0.42 mmol/L as compared to the control group i.e. 1.48 ± 0.27 mmoI/L where p < 0.05 as well as Triacylglycerols and Total Cholesterol had highly significant correlation with NIDDM.