To Determine the Frequency of Clinical Remission Induction with Versus without Fecal Microbiota Transplant in Treatment of Active Ulcerative Colitis

To Determine the Frequency of Clinical Remission Induction with Versus without Fecal Microbiota Transplant in Treatment of Active Ulcerative Colitis

Authors

  • Attique Abou Bakr Department of Gastroenterology, AIMC/ Jinnah Hospital Lahore
  • Shahid Sarwar Department of Gastroenterology, AIMC/ Jinnah Hospital Lahore
  • Muhammad Naeem Aslam Department of Gastroenterology, Mayo Hospital Lahore
  • Mamoona Ghias 3Department of Medicine, Mayo Hospital Lahore
  • Muhammad Nadeem Yousuf Department of Gastroenterology, AIMC/ Jinnah Hospital Lahore

DOI:

https://doi.org/10.21649/akemu.v30i1.5188

Keywords:

Ulcerative colitis, Fecal Microbiota Transplant, Mayo score .

Abstract

Background: Ulcerative colitis is a long lasting inflammatory disease of the intestines that gets worse over time.

Objective:. The goal of this study was to compare the success rates of inducing clinical remission in patients with active Ulcerative Colitis who underwent treatment with or without Fecal Microbiota Transplant.

Methods: It was a Randomized Controlled Trial, which was done in Department of Gastroenterology/Medical Unit II of Jinnah Hospital Lahore .Study duration was 18months (from 01-01-2021 to 30-06-2022). The research included 90 patients who were randomly assigned to two groups. Standard Ulcerative Colitis therapy was given to both groups. Patients in group A recieved  once-weekly faecal microbiota transplant for a period of six weeks. Patients in group B had weekly water enemas for same period. All patients underwent colonoscopy and Mayo score was noted before treatment, and after 6 weeks of treatment. Clinical remission was labeled if patients achieved Mayo score £2 after treatment.

Results: Group A (Treatment) had a mean age of 39.31 ±13.45 and group B (Control) had a mean age of 38.59 ±12.11 (p=0.52). Duration of ulcerative colitis in group A was 8.08±2.64 weeks and in group B was 9.00±2.62 weeks (p=0.76). Pre-treatment Mayo score in groups A and B, were 8.29±1.91in  and 8.73 ±1.61 respectively (p=0.15). Post-treatment in group A, the Mayo score was 3.71± 2.22, whereas in group B, it was 5.07± 1.75 (p=0.003). Remission was achieved in 24.44% (n=11) in fecal microbiota transplant group and 8.88% (n=4) in control group. (p=0.003).

Conclusion: When compared to the control group, FMT significantly induces remission in patients with active UC.

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Published

03/29/2024

How to Cite

Bakr, A. A., Sarwar, S., Aslam, M. N., Ghias, M., & Yousuf, M. N. (2024). To Determine the Frequency of Clinical Remission Induction with Versus without Fecal Microbiota Transplant in Treatment of Active Ulcerative Colitis. Annals of King Edward Medical University, 30(1), 45–51. https://doi.org/10.21649/akemu.v30i1.5188

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