Blood Pressure and Risk of Bleeding During Permcath Insertion
DOI:
https://doi.org/10.21649/akemu.v32i1.5952Keywords:
End-stage renal disease, Haemodialysis, hypertension, vascular accessAbstract
Background: The tunnelled double-lumen cuffed catheter (TDLCC) is commonest route of vascular access with risk of bleeding from its insertion site.
Objective: To assess the effect of blood pressure on the risk of bleeding during tunnelled double-lumen catheter placement for haemodialysis.
Methods: This study was carried out on patients who were ≥ 18 years old and required vascular access for haemodialysis. Patients having patent arteriovenous fistula, coagulopathy, and thrombocytopenia were excluded. All the patients were observed for haemodynamic instability and bleeding from the site of TDLCC insertion.
Results: There were one hundred and forty (n=140) individuals, including 97 (69.29%) males, with a mean age of 56.21±14.86 years. The bleeding during TDLCC insertion was observed in 24 (17.14%) patients. The mean systolic blood pressure was 138.69±19.09 mmHg, while the mean diastolic BP was 85.89±12.31 mmHg. The receiver operating curve analysis of systolic blood pressure for the risk of bleeding showed the area under curve 0.792(95% confidence interval 0.697 - 0.886, p<0.001) and for diastolic blood pressure, the area under curve came out to be 0.767(95% confidence interval 0.662 - 0.871, p<0.001). The area under curve for serum creatinine was 0.654(95% confidence interval 0.536 – 0.772, p=0.017). The best cut-off values for systolic and diastolic blood pressure and serum creatinine for predicting bleeding risk were 142.50 mmHg, 92.50 mmHg, and 691.50 µmol/L, respectively.
Conclusion: The blood pressure has a significant effect on the risk of bleeding during the insertion of a tunnelled double-lumen catheter in haemodialysis patients.
References
1. Ball M, Singh A. Care of a Central Line. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564398/.
2. Arasu R, Jegatheesan D, Sivakumaran Y. Overview of hemodialysis access and assessment. Can Fam Physician. 2022;68(8):577-82. doi: 10.46747/cfp.6808577.
3. Azeem SM, Ehsan O, Khan MI. Patency and Complications of Arterio-venous Fistula Created in Pre- and Post-dialysis Settings. J Coll Physicians Surg Pak. 2022;32(4):510-13. doi: 10.29271/jcpsp.2022.04.510.
4. Lok CE, Huber TS, Orchanian-Cheff A, Rajan DK. Arteriovenous Access for Hemodialysis: A Review. JAMA. 2024;331(15):1307-17. doi: 10.1001/jama.2024.0535.
5. Lok CE, Huber TS, Lee T, Shenoy S, Yevzlin AS, Abreo K, et al. KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update. Am J Kidney Dis. 2020;75(4):1-164. doi: 10.1053/j.ajkd.2019.12.001.
6. Hoogeveen EK. The epidemiology of diabetic kidney disease. Kidney Dial. 2022;2(3):433-42. doi:10.3390/kidneydial2030038.
7. Burnier M, Damianaki A. Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease. Circ Res. 2023;132(8):1050-63. doi: 10.1161/CIRCRESAHA.122.321762.
8. Ablordeppey EA, Huang W, Holley I, Willman M, Griffey R, Theodoro DL. Clinical Practices in Central Venous Catheter Mechanical Adverse Events. J Intensive Care Med. 2022;37(9):1215-22. doi: 10.1177/08850666221076798.
9. Eljaafary AE, Elsabbagh MA, Abdelrahim MG, Ahmed MF, Mahmoud MI. Overview about Complications of Central Venous Catheters of Hemodialysis and Their Prevention in Adults. Egypt J Hosp Med. 2023;91(1):4554-59. doi: 10.21608/ejhm.2023.297776
10. Pezeshkmehr A. Principles of Vascular Access and Complications. In: Gilani R, Mills Sr JL, editors. Vascular Complications of Surgery and Intervention: A Practical Guide. Cham: Springer International Publishing; 2022. 127-48.
11. Beathard GA, Urbanes A, Litchfield T. The risk of bleeding with tunnelled dialysis catheter placement. J Vasc Access. 2016;17(5):397-400. doi: 10.5301/jva.5000586.
12. Hamid RS, Kakaria AK, Khan SA, Mohammed S, Al-Sukaiti R, Al-Riyami D, et al. Safety and Complications of Double-Lumen Tunnelled Cuffed Central Venous Dialysis Catheters: Clinical and radiological perspective from a tertiary centre in Oman. Sultan Qaboos Univ Med J. 2015;15(4):501-6. doi: 10.18295/squmj.2015.15.04.010
13. Vuthaluru S, Krishna A. Step-by-Step Guide to Averting and Managing a Central Line Insertion Misadventure. Indian J Vasc Endovasc Surg. 2020;7(4):444. doi: 10.4103/ijves.ijves_103_20
14. Ali L, Ali T, Mustafa SI, Qureshi AA. Experience of permacath placement in patients with end-stage renal failure in a tertiary hospital. Anesth Pain Intens Care. 2023;27(6):726–30. doi: 10.35975/apic.v27i6.2357.
15. Kander TK, Schött US. Bleeding complications after central line insertions and the relevance of pre-procedure coagulation tests and blood component therapy. Crit Care. 2013;17(2):358. doi: 10.1186/cc12296.
16. Shimamura Y, Maeda T, Abe K, Takizawa H. Association of blood pressure with mortality in hemodialysis patients with a tunneled cuffed catheter: A single-center observational study. Medicine (Baltimore). 2020;99(37):22002. doi:10.1097/MD.0000000000022002.
17. Coeckelenbergh S, Van Nuffelen M, Mélot C. Sepsis is frequent in initially non-critical hypotensive emergency department patients and is associated with increased mortality. Am J Emerg Med. 2019;37(12):2242-45. doi: 10.1016/j.ajem.2019.158360.
18. Chaudhry R, Miao JH, Rehman A. Physiology, Cardiovascular. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493197/
19. van de Weerdt EK, Biemond BJ, Baake B, Vermin B, Binnekade JM, van Lienden KP, et al. Central venous catheter placement in coagulopathic patients: risk factors and incidence of bleeding complications. Transfusion. 2017;57(10):2512-25. doi: 10.1111/trf.14248.
20. Diaz C, Quintero JA, Zarama V, Bustamante-Cristancho LA. Bleeding Complications in Uremic Patients After Ultrasound-Guided Central Venous Catheter Placement. Open Access Emerg Med. 2023;15:21-8. doi: 10.2147/OAEM.S384081.
21. Bream PR Jr. Update on Insertion and Complications of Central Venous Catheters for Hemodialysis. Semin Intervent Radiol. 2016;33(1):31-8. doi: 10.1055/s-0036-1572547.
22. Ocak G, Rookmaaker MB, Algra A, de Borst GJ, Doevendans PA, Kappelle LJ, et al. Chronic kidney disease and bleeding risk in patients at high cardiovascular risk: a cohort study. J Thromb Haemost. 2018;16(1):65-73. doi: 10.1111/jth.13904.
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Annals of King Edward Medical University

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments publications@kemu.edu.pk