Goserline versus danazol in the treatment of endometriosis
Keywords:Danazol. Endometriosis. Drug Toxicity. Estrogen Antagonists. Pharmaceutical Preparations. Pelvic Pain. Leuprolide. Nafarelin. Gestrinone.
Objective: The objective of this study was to achieve symptoms relief of endometriosis with a drug having better efficacy and least side effects. Study Design: Experimental. Place & Duration of Study: Lady Willingdon Hospital, Lahore from March, 2003 to Feb. 2005. Subjects & Methods: The trial was conducted on two groups; one group (n = 20) received goserline and other group (n=20) received danazol for 6 months. Patients were followed for relief of symptoms including dysmenorrhoea, dyspareunia, lower abdominal pain and menstrual irregularity and appearance of side effects. Results: The results depicted that in Danazol group 50% pain relief was found in 5 patients (25%) while in goserline group in 4 patients (20%). 75% pain relief was seen in 7 patients (35%) in danazol group and 8 patients (40%) in goserline group. 100% of improvement in pain found in equal number of patient that is 8(40%) in both groups. Both drugs were effective in pain relief (P >0.05), Goserline had less side effects as compared to Danazol (P<0.05). Conclusion: Goserline and Danazol are equally effective in symptomatic relief of endometriosis while side effects favoured use of GnRH agonist.
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