Ovarian Drilling for Clomiphene Citrate Resistant Polycystic Ovarian disease

Abstract

This study was conducted at National University Hospital Singapore and Surgimed Hospital (Teaching Hospital) rom 30th June 1998 to 241h April, 2001. 140 patients were recruited. This study evaluated the outcome of laparoscopic ovarian drilling in 140 patients who failed to conceive on clomiphene citrate (treatment started from minimum dose of 50 mg/day to 150 mg/day from day 2-6 of menstrual cycle). Various symptoms were evaluated which were infertility (72.8 % primary, secondary infertility 27.2 %), menstrual problems, hirsutism and obesity. In every case 8-10 holes were created in 1)0th the ovaries. Levels of the raised hormone were significantly reduced. By the end of first year 82% had normal menses, 71.6 % ovulated spontaneously 56% were pregnant. At 18 month 6 % were pregnant and 78 % at the end of two years.