Comparison of Association of Diabetes Mellitus in Hepatitis C Virus Infection and Hepatitis B Virus Infection

Abstract

Abstract

Background:  While patients with liver disease are known to have a higher prevalence of glucose intolera-nce, preliminary studies suggest that hepatitis C virus (HCV) infection may be an additional risk factor for the development of diabetes mellitus (DM).

Objective:  The presented study was aimed to study and determine a relationship between the relative pro-portions of Diabetes Mellitus in patients suffering from HCV infection.

Study Design:  This cross sectional study.

Study Settings:  Patients were registered from outdoor as well as indoor departments of different teaching hospitals (Services hospital Lahore and medical depar- tments in Jinnah hospital, Mayo hospital, Sir Ganga Ram hospital) in Lahore, Pakistan.

Methods:  This cross sectional study was comprised of age and sex matched 258 patients of viral hepatitis B infection and viral hepatitis C infection, conducted at Hepatitis Clinic Services Hospital, affiliated with Post Graduate Medical Institute, Lahore. Diagnosis of HBV was made with evidence of hepatitis B surface antigen, HCV infection was diagnosed if patient was sero positive for anti HCV (ELISA methods) and
HCV - RNA (By PCR). Diabetes Mellitus was diag-nosed after fulfilling the "American Diabetic Associ-ation Criteria", from November, 2000 to September, 2002.

Results:  A total of 318 patients were registered, out of which 258 cases fulfilled the inclusion criteria, 164 hepatitis C infected and 94 hepatitis B infected cases, 16.46% hepatitis C infected cases were diagnosed as diabetics while 4.25% hepatitis B infected cases were diagnosed as diabetics.

Conclusion:  This study concludes that there is high Association and relationship of Diabetes Mellitus with Hepatitis C virus infection as compared with Hepatitis B virus infection.

Key words:  Hepatitis B, Hepatitis C, diabetes Melli-tus.