Intranasal Dexmedetomidine as Sedative for Non-Invasive Pediatric Diagnostic Procedures Outside Operating Room

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Intranasal Dexmedetomidine as Sedative for Non-Invasive Pediatric Diagnostic Procedures Outside Operating Room

Authors

  • Ahmed Bilal Akhtar
  • Muhammad Khurram Ijaz
  • Adeel Bashir
  • Ahsun Waqar Khan

DOI:

https://doi.org/10.21649/akemu.v28i2.5083

Keywords:

Intranasal, dexmedetomidine, pediatric, diagnostic, sedative, non-invasive

Abstract

Background: Children often require sedation for long non-invasive diagnostic procedures. Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist with sedative, anxiolytic and analgesic properties. It mimics natural sleep and allows patients to easily arouse with minimal effects on respiration and airway patency. Objective: To assess the successful completion of pediatric non-invasive diagnostic procedures with intranasal dexmedetomidine as a sedative agent. Methods: Seventy-nine subjects of age six months to twelve years scheduled for non-invasive diagnostic procedures were included. Dexmedetomidine (4 mcg/kg) was administered intranasally 25 minutes before the scheduled time of procedure. A sedation score of two or above as per the MICHIGAN sedation scale was considered satisfactory for starting the procedure. Results: Seventy-four (95%) out of the seventy-nine subjects were successfully sedated with Intranasal dexmedetomidine (p<0.0001). The mean time and Standard deviation to achieve sedation was 18.9 ± 2.82 mins. The median time was 19 mins with a range from 15-25 minutes. Post anesthesia discharge time for Intranasal dexmedetomidine was 20 minutes with zero incidence of post procedure nausea and vomiting. Conclusions: Intranasal dexmedetomidine can be used as an alternative to General anesthesia for non-invasive diagnostic procedures outside operating room with less adverse effects in this cohort.

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Published

07/19/2022

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How to Cite

Akhtar, A. B. ., Ijaz, M. K. ., Bashir, A. ., & Khan, A. W. . (2022). Intranasal Dexmedetomidine as Sedative for Non-Invasive Pediatric Diagnostic Procedures Outside Operating Room. Annals of King Edward Medical University, 28(2). https://doi.org/10.21649/akemu.v28i2.5083

Issue

Vol. 28 No. 2 (2022): AKEMU

Section

Research Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments publications@kemu.edu.pk