Dengue Hemorrhagic Fever: Risk Factors in Pakistani Cohort

Dengue Hemorrhagic Fever: Risk Factors in Pakistani Cohort

Authors

  • Aliza Anjum Department of Medicine, Allama Iqbal Medical College Lahore/ Jinnah Hospital Lahore
  • Arfa Ahmed Assad Department of Medicine, Allama Iqbal Medical College Lahore/ Jinnah Hospital Lahore
  • Ayesha Sadia Department of Medicine, Allama Iqbal Medical College Lahore/ Jinnah Hospital Lahore
  • Aleeza Maimoona Department of Medicine, Allama Iqbal Medical College Lahore/ Jinnah Hospital Lahore
  • Shahid Sarwar Department of Medicine, Allama Iqbal Medical College Lahore/ Jinnah Hospital Lahore

DOI:

https://doi.org/10.21649/akemu.v30i1.5494

Keywords:

Dengue fever, Dengue hemorrhagic fever, Predictors

Abstract

Background: Dengue fever is a mosquito-borne infectious disease with potential complications such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)  and has fatality risk of greater than 20% if left untreated. There is lot of heterogeneity in factors predicting development of DHF in different populations.

Objective:  To determine clinical, biochemical and radiological parameters associated with risk of developing DHF in Pakistani population.

Methods: This prospective observational study was conducted in Jinnah Hospital Lahore from October 2022 to December 2022. 180 patients with confirmed Dengue fever were included. Detailed history, clinical examination and laboratory/radiological investigations were performed. Patients were followed for development of DHF. Univariate analysis followed by logistic regression analysis was used to determine independent predictors for DHF.

Results: Among 180 patients with  Dengue fever with mean age of 33.04 (+14.12) and male to female ratio of 1.53/1 (109/71), we identified presence of mucosal bleeding {OR 4.7 (95% CI 2.05-10.78)p value <0.000}, abdominal pain {OR 2.73 (95% CI 1.17-4.38)p value 0.013}, persistent vomiting {OR 3.09 (95% CI 1.51-6.34)p value 0.002}, tender right hypochondrium {OR 3.98 (95% CI 1.94-8.16) p value <0.000} and presence of peri-cholecystic fluid {OR 7.78 (95% CI 3.25-18.63)p value < 0.000} to be significantly associated with risk of developing DHF with 83.6% accuracy on logistic regression analysis.

Conclusion: Mucosal bleeding, right hypochondrium pain, persistent vomiting and presence of peri-cholecystic fluid in a patient of dengue fever predict risk of developing dengue hemorrhagic fever.

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Published

03/25/2024

How to Cite

Anjum, A., Assad, A. A., Sadia, A., Maimoona, A., & Sarwar, S. (2024). Dengue Hemorrhagic Fever: Risk Factors in Pakistani Cohort. Annals of King Edward Medical University, 30(1), 70–75. https://doi.org/10.21649/akemu.v30i1.5494

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Section

Research Articles

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