Family History of Diabetes and Parental Consanguinity: Important risk for Impaired Fasting Glucose

Abstract

Abstract

Objective:  Offspring of type 2 diabetics have incre-ased risk of metabolic disturbances. The aim of the study was to access the potential effect of family his-tory of type 2 diabetes (FHD) and parental consangui-nity on fasting plasma glucose (FPG) levels.

Design:  Non diabetic offspring of one or both parents with type 2 diabetes and healthy controls of compar-able age, without a FHD were the subjects of this stu-dy. FHD was defined by the presence of type 2 diabe-tes in one or both parents of the subject. Consanguinity was defined as history of marriage with first cousin. FPG levels were determined in cases and controls.

Results:  IFG was identified in 42% subjects with a FHD and in 14% without FHD. We found a strong in-dependent association of FHD with impaired fasting glucose in both males and females by logistic regres-sion analysis after adjusting the data for age sex and BMI. Parental consanguinity modifies the effect of FHD on IFG.

Conclusion:  We concluded that family history of dia-betes and parental history of consanguinity determine the risk for impaired fasting glucose in our population.

Keywords:  Impaired fasting glucose; Parental con-sanguinity; Family history of diabetes.