Correlation Between Alanine Aminotransferase and Left Ventricular Mass in Patients with Non-Alcoholic Fatty Liver Disease

  • Muhammad Arshad Khan Mayo Hospital, Lahore
  • Ali Asad Khan King Edward Medical University/Mayo Hospital, Lahore
  • Yasir Shafi Mayo Hospital, Lahore
  • Faisal Masood Mayo Hospital, Lahore
  • Sidrah Lodhi King Edward Medical University/Mayo Hospital, Lahore
  • Sajid Abaidullah King Edward Medical University/Mayo Hospital, Lahore
Keywords: Alanine aminotransferase, Transaminitis, Left ventricular mass, Non-alcoholic fatty liver disease

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for chronic kidney disease, endocrinopathies, cardiovascular disease (CVD), cerebrovascular disease and osteoporosis. Many prospective follow-up studies demonstrated cardiovascular mortality as an important cause of death in these patients. However, the exact relationship between ALT and CVD especially LVH is undetermined.

Objective: The objective of this study was to determine the correlation between raised ALT levels and left ventricular mass (LVM) in NAFLD patients.

Methods: In this cross sectional analytical study, 115 patients (both male and female) were selected through non-probability purposive sampling technique after meeting inclusion and exclusion criteria. These patients, aged 20-60 years, were diagnosed cases of NAFLD with transaminitis (ALT ≥40 unit/L). Venous samples were collected for ALT, viral serology and fasting lipid profile. All the patients underwent ultrasound abdomen and echocardiography for LVM.

Results: Mean age of patients was 44.63±1.03 while gender distribution showed 55(47.8%) male and 60(52.2%) female patients with a mean body mass index (BMI) of 26.75±5.048. Mean ALT level was 56.68±9.08 and mean LVM was 190.60±14.23 grams. Correlation coefficient for ALT and LVM was 0.571 which showed moderate correlation between these two parameters. A positive moderate correlation existed between ALT and LVM after stratifying the data according to age, gender and BMI.

Conclusion: Elevated ALT levels in NAFLD patients can serve as a screening tool for cardiovascular risk assessment. Whether there is a temporal relationship between transaminitis and an increased risk of cardiovascular events needs further statistical evidence.

Author Biographies

Muhammad Arshad Khan, Mayo Hospital, Lahore

Medical Officer, Department of North Medicine,

Mayo Hospital, Lahore

Ali Asad Khan, King Edward Medical University/Mayo Hospital, Lahore

Assistant Professor, Department of North Medicine,

KEMU/ Mayo Hospital, Lahore

Yasir Shafi, Mayo Hospital, Lahore

Medical Officer, Department of North Medicine,

Mayo Hospital, Lahore

Faisal Masood, Mayo Hospital, Lahore

Senior Registrar, Emergency Medicine,

Mayo Hospital, Lahore

Sidrah Lodhi, King Edward Medical University/Mayo Hospital, Lahore

Assistant Professor, Department of North Medicine,

KEMU/ Mayo Hospital, Lahore

Sajid Abaidullah, King Edward Medical University/Mayo Hospital, Lahore

Professor and Head of North Medicine,

KEMU/ Mayo Hospital, Lahore

Published
2019-12-30
How to Cite
Muhammad Arshad Khan, Ali Asad Khan, Yasir Shafi, Faisal Masood, Sidrah Lodhi, & Sajid Abaidullah. (2019). Correlation Between Alanine Aminotransferase and Left Ventricular Mass in Patients with Non-Alcoholic Fatty Liver Disease. Annals of King Edward Medical University, 25(4). Retrieved from https://annalskemu.org/journal/index.php/annals/article/view/3126
Section
Articles