Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Muhammad Khalid Ch; Muhammad Saqib Saeed; Rizwan Iqbal; Akhtar Ali

doi:10.21649/akemu.v22i1.803

Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy

Authors

Muhammad Khalid Ch
Muhammad Saqib Saeed
Rizwan Iqbal
Akhtar Ali

DOI:

https://doi.org/10.21649/akemu.v22i1.803

Keywords:

Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

Abstract

Abstract

Background: Tuberculous pleurisy is a common extrapulmonary manifestation and is second to tuberculous lymphadenitis. Due to its paucibacillary in origin, its diagnosis is a challenge. Furthermore, it is also complicated by the emergence of MDR. Gene Xpert MTB/RIF is a new rapid promising innovation for the detection of mycobacterium tuberculosis and its resistance to Rifampicin, giving result within two hours.

Objective: To evaluate the diagnostic role of Gene Xpert MTB/RIF in suspected cases of tuberculous pleurisy.

Study Design: Cross sectional study.

Study Setting: Institute of Chest Medicine Mayo Hospital – a Tertiary Care Hospital affiliated with King Edward Medical University, Lahore.

Methodology: The study group, one hundred (M-60 and F-40) cases having exudative, predominantly lymphocytic pleural effusion with strong suspicion of tuberculous in origin were enrolled randomly for Gene Xpert MTB / RIF.

Results: Among one hundred study cases, Gene Xpert detected mycobacterium tuberculosis in 12(12%) cases [M-8 (13.3%) and F-4 (10%)]. Resistance to Rifampacin was detected in 6 (6%) cases [M-2 (3.3%) and F-4 (10%)].

Conclusion: Gene Xpert MTB/RIF is a useful new rapid promising technique to diagnose tuberculous pleurisy. Although at present it has limited availability and utility.

Key Words: Gene Xpert. MTB – Mycobacterium tuberculosis. RIF – Rifampacin. TB – Tuberculosis. MDR – Multidrug resistance.

Downloads

Published

02/13/2016

How to Cite

Ch, M. K., Saeed, M. S., Iqbal, R., & Ali, A. (2016). Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy. Annals of King Edward Medical University, 22(1), 78. https://doi.org/10.21649/akemu.v22i1.803

Download Citation

Issue

Vol. 22 No. 1 (2016): AKEMU

Section

Medicine & Allied

License

This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments publications@kemu.edu.pk

Most read articles by the same author(s)

Salman Ayyaz, Affaf Javaid, Asif Hanif, Yasir Nasir, Afshan Qureshi, Shakeel Ahmed, Bilal Mushtaq, Abdul Wajid Khan, Seemab Paul, Muhammad Atif, Muhammad Saleem, Farrukh Afzal, Muhammad Saqib Saeed, Effectiveness of Noninvasive Positive Pressure Ventilation in COVID-19 Patients with Severe Acute Respiratory Distress Syndrome , Annals of King Edward Medical University: Vol. 27 No. 2 (2021): AKEMU
Muhammad Kashif Munir, Sana Rehman, Rizwan Iqbal, Muhammad Saqib Saeed, DEVELOPMENT OF MDR TB IN SHORT DURATION IN A PATIENT RECEIVING TREATMENT FOR SIMPLE TB: A CASE REPORT , Annals of King Edward Medical University: Vol. 21 No. 4 (2015): AKEMU
Tania Shakoori, Khaula Tariq, Muhammad Saqib Saeed, Maham Ahmed, Aftab Asif, Elevating the MD/MS/MDS Qualification: A Curriculum Update from a Public Sector Medical University, Lahore, Pakistan , Annals of King Edward Medical University: Vol. 24 No. 2 (2018): AKEMU
Muhammad Khalid Chaudhry, Muhammad Saqib Saeed, Rizwan Iqbal, Sajjad Hassan, TUBERCULOUS PLEURISY â€“ DIAGNOSTIC YIELDS OF PLEURAL FLUID MYCOBACTERIAL SMEAR AND CULTURE , Annals of King Edward Medical University: Vol. 21 No. 3 (2015)
Muhammad Khalid Ch., Sajjad Hassan, Muhammad Saqib Saeed, Muhammad Younus, Rizwan Iqbal, DRUG RESISTANCE PATTERN AMONG AFB SMEAR POSI-TIVE RETREATMENT COMPLETED CASES , Annals of King Edward Medical University: Vol. 21 No. 1 (2015)
Afshan Qureshi, Salman Ayyaz, Asif Hanif, Yasir Nasir, Muhammad Saqib Saeed, The Role of B-Lines on Transthoracic Ultrasonography in Patients of Interstitial Lung Disease , Annals of King Edward Medical University: Vol. 26 No. 2 (2020): AKEMU
Muhammad Khalid Ch., Muhammad Younus, Sohail Anwer, Irrum Aneela, Muhammad Saqib Saeed, Asthma Management in Pregnancy: Young Female Doctors Knowledge and Practice , Annals of King Edward Medical University: Vol. 18 No. 4 (2012)
Muhammad Saqib Saeed, Afshan Qureshi, Salman Ayyaz, Asif Hanif, Hassan Shafique Butt, Radiological and Clinical Pattern in Severely/Critically ill COVID–19 Positive Patients , Annals of King Edward Medical University: Vol. 26 No. 3 (2020): AKEMU

Gene Xpert MTB / RIF – Diagnostic Role in Tuberculous Pleurisy