Glimepiride - A Short Term Trial of the Clinical Efficacy

Abstract

Diabetes is a common disorder and is reaching epidemic proportions especially in the third world. In the last few years new drugs have emerged targeting at better pharmacokinetic and low side effect profile. Among them have been various insulin sensitizers and newer sulfonylurias. Glimepiride with an impressive tract record offered more benefits and improved quality of life. The clinical efficacy in relation to the commonly used or traditional sulfonylurias was thus evaluated in this short term open trial involving 48 patients. The objective was to determine the clinical efficacy, tolerability, side effect profile and the equivalent dose of glimepiride compared to conventional sulphonylurias. The advantages  of this new second generation sulfonyluria are discussed.