Diabetes Mellitus Among Patients with Cirrhosis Due to Hepatitis C Virus and its Association with Hepatic Encephalopathy

Abstract

Background: Diabetes Mellitus (DM) is frequent in chronic liver disease and there is an increased association of DM with Hepatitis C andhepatic encephalopathy (HE). In our setup such studies are not published and we do not have the updated knowledge of the above mentioned phenomena. Objectives: To determine the frequency of DM in HCV cirrhotic patients and association of HE in HCV Cirrhotic patients with DM Materials And Methods: This Analytical cross-sectional study was conducted in Medicine Department, Mayo hospital, Lahore.100 patients with HCV associated cirrhosis were included using non-probability purposive sampling. Patients were stratified as diabetic and non-diabetic according to ADA criteria and presence of HE was determined clinically. Frequency and percentage of HE & diabetes were calculated and odds ratio was calculated to determine association. P-value <0.05 was considered significant. Results: The mean age of patients was 44.43±10.16 years and there were 66% males and 34% females. 34% among HCV cirrhosis patients were diabetic. HE was seen in 31(91.2%) of the diabetic patients and in 48(72.7%) of non-diabetic patients with odds ratio of 3.875 (p-value 0.016) Conclusion: There is a significant association between diabetes mellitus and HE among patients with HCV associated cirrhosis.