Microscopic changes induced by Cr-Vi in spleen of albino mice

Abstract

Chromium is believed to be an essential trace element in human nutrition. Evidence suggests that it plays an important role in normal carbohydrate metabolism. It was found that patients receiving long-term total parenteral nutrition (TPN) without chromium developed glucose intolerance, weight loss and peripheral neuropathy Chromium is present in a normal diet at trace (but essential) levels. Occupational exposure is related to the industrial uses of chrome compounds in production and use of steels, pigments, leather tanning and wood preservation solutions, plating chemicals, and cement. Toxicity is predominantly associated with industrial exposures. Hexavalent chromium compounds appear to have greatest toxicity and almost all tissues of body are affected. To evaluate the effects on lymphoid tissue, present study was carried out. The mice of experimental group (2wks, 4wks, 6wks and 8wks) were injected Potassium dichromate (K2Cr2O7) intraperitoneally according to experimental design. The drug caused slight to marked hyperplasia of lymphoid follicles and dilatation of sinuses of red pulp depending upon duration of exposure. Aggregates of hemosidrin-laden macrophages were also seen indicating heamolytic effects on RBCs.