Coagulation profile in albino rats fed on canola oil supplemented with atherogenic element: A study for 12 weeks

Abstract

Present study was designed to estimate the coagulation parameters like prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen level. In this study, coagulation parameters were compared in animals fed on low and high cone. of canola oil with that of canola supplemented with atherogenic element. For this purpose sixty albino rats were selected and divided into five different groups with twelve rats in each group. Group A was given synthetic diet (control) and other four groups (B, C, D and E) were given low and high cone. of canola oil and canola oil + atherogenic elements for 12 weeks duration. Blood samples were collected at 12th week duration in all the groups. PT and APTT were reduced in group containing different cone. of canola oil + atherogenic element when comparing with groups on pure canola oil. Fibrinogen level was increased in groups C and E when comparing with groups on low and high cone. of pure canola oil for prolonged use i.e. 12 weeks. The present study shows the beneficial effects of canola oil on coagulation profile. Thus canola oil may be recommended for human consumption in this country to reduce the incidence of ischemic heart disease.