Perioperative Use of Low Dose Dopamine Protects Against Renal Injury in Patients Undergoing on-Pump Coronary Artery Bypass Surgery

Abstract

Abstract
Objectives: To compare and determine the effects of low dose dopamine in prevention of renal injury during cardiopulmonary bypass in patients undergoing isolated coronary artery bypass graft surgery.
Methods: Group I (n=25 patients) had mannitol 1g/Kg in the priming circuit and low dose dopamine (2ug/Kg/min) was administered in perioperative period starting at induction of anesthesia and continued till postoperative day 3. Group-II (n=25 patients) also had mannitol 1g/Kg in the priming circuit but dopamine was not administered in the perioperative period. The groups were matched in terms of patient characteristics and preoperative creatinine levels. Highest postoperative creatinine level within 5 days was taken as marker of renal injury. Student's t-test was used to assess the significance of differences in creatinine levels in two groups.
Results: There was a marginal increase in the postoperative creatinine level in group II patients, however this increase was statistically significant (p= 0.016).

Conclusion: We conclude that low dose of dopamine during perioperative period in patients undergoing coronary artery bypass surgery on cardiopulmonary bypass has a contributing factor in renal preservation.